主要承担项目及成果(项目、论文、专利、获奖) |
一、荣誉称号及获奖 1. 陕西科技大学 学术骨干、药学学科带头人 2. 浙江省高校中青年学科带头人(2013); 3. 入选浙江省“新世纪151人才工程”(2009); 5. 浙江省科学技术奖三等奖;基于羰基化合物高选择性合成杂环化合物的研究;浙江省人民政府;谢建武(排名1/6);2013年; 6. 中国科学院院长优秀奖(2007); 7. 中国科学院西部学子奖学金(2006,2007); 8. 浙江省第十四届挑战杯一等奖,基于[3+2]环加成反应合成抗菌化合物及溴虫腈的研究,指导教师:谢建武 (1/1),2015年; 9. 第六届浙江省大学生化学学科竞赛,非均相无溶剂下一锅法高效合成1, 4- 二氢吡啶 浙江省化学会 一等奖,指导教师:谢建武(1/2),2014年; 二、承担项目 1. 基于1,3-二羰基化合物的串联反应高选择性合成杂环化合物的研究 国家自然科学基金面上项目 21272214 2.新颖手性有机催化剂在不对称催化1,3-质子迁移和三氟甲基化反应的应用 国家自然科学基金青年基金 20902083 3.有机催化不对称合成光学纯的三氟甲基化合物5 浙江省自然科学基金 Y4090082 4.基于手性胺出发的新型催化剂的合成及应用 浙江省科技厅 2009R50020-13 5. 有机小分子催化的不对称串联反应研究KJ20080125 6. 2-羟基吡啶N-氧化物的合成工艺研发 浙江野风药业有限公司 KJH2010030 7. 2,3-二氢呋喃衍生物的绿色合成工艺技术开发KJ20100204 8. 华法林药物的合成工艺研发 兰溪康恒医药化工有限公司 KJH2012045 9. 六氟丙烯下游产品合成技术开发 浙江巨化技术中心有限公司 三、代表论文 2020年 51. Li-Jun Chen, Jin-Hang Yu, Bin He, Jian-Wu Xie, Yuan-Xiu Liu, and Wei-Dong Zhu, Umpolung Strategy for the Synthesis of Chiral Dispiro[2-amino-4,5-dihydrofuran-3-carbonitrile]bisoxindoles, J. Org. Chem. 2020, 85, 7793−7802. 2019年 50. L.-S.-H. Yu, J. Wang, Z.-J. Gao, J.-W. Xie, Substrate-Controlled Diastereoselectivity Switch in the Formation of Dihydrothiophene Derivatives via [4+1] Annulations, Adv. Synth. Catal., 2019, 361, 526-534. 2018年 49. J.-L Dong, L.-S.-H. Yu, J.-W. Xie*, A Simple and Versatile Method for the Formation of Acetals/Ketals Using Trace Conventional Acids, ACS Omega, 2018, 3, 4974-4985. 48. J.-L Dong, P.-S. Wei, L.-S.-H. Yu, J.-W. Xie*, Chemoselective Synthesis of Structurally Diverse 3,4-dihydroquinazoline-2(1H)-thiones and 4H-benzo[d][1,3]thiazines J. Org. Chem. 2018, 83, 2219-2226. 47. L.-S.-Han Yu, J.-Li. Dong, Z.-J. Gao, J. Wang, J.-W. Xie, Construction of Functionalized (Dihydro)thieno[2,3-c]chromene Derivatives via a Domino Michael Addition/Intramolecular Cyclization Reaction Synthesis., 2018, 50(08), 1667-1674. 46. J-W. Zhang, L.-S.-H. Yu, J.-L. Dong, Q.-C. Sun, J.-W. Xie*, Enantioselective Construction and Transformations of Polyfunctionalized 3,4-Dihydro-2H-thiopyrano[2,3-b]quinolines, Synlett., 2018, 29,603-608. 45. C.-H. Ding, J.-L. Dong, L.-S.-H. Yu, J.-W. Xie, Organocatalytic Domino Michael/cyclization for the synthesis of highly substituted 4, 5-dihydrothiophenes, Chinese Chem. Lett. 2018, 29, 517-520. 2017年 44. X.-N. Ping, P.-S. Wei, X.-Q. Zhu, J.-W. Xie*, Catalyst-Controlled Switch in Diastereoselectivities: Enantioselective Construction of Functionalized 3,4-Dihydro-2H-thiopyrano[2,3-b]quinolines with Three Contiguous Stereocenters, J. Org. Chem. 2017, 82, 2205-2210. 2016年 43 X.-N. Ping, W. Chen, X.-Y. Lu and J.-W. Xie*, Efficient synthesis of functionalized spiro[imidazolidine-2-thione-oxindoles] via catalyst-free domino Mannich cyclization, Arkivoc, 2016 (vi), 274-283. 42. X.-Q. Zhu, J.-S. Wu, J.-W. Xie *, Stereoselective Construction of Bi-spirooxindole Frameworks via a Michael Addition/Cyclization and an Unexpected Redox/Oxidative Coupling/Cyclization, Tetrahedron, 2016, 72, 8327-8334. 41. X.-Y. Zhang, Z. Shen, L.-L. Hua, L.-J. Wang, Y.-S. Lin, J.-W. Xie*, H.-L. Cui*, Microwave-assisted organocatalysis: phosphine-mediated Tomita Zipper cyclization affording functionalized spirooxindole, Tetrahedron Lett. 2016, 57, 3790–3794. (影响因子:2.379) 40. X.-M. Zeng, J.-W. Xie*, Enantioselective Synthesis of Ring-Fused Spiroannulated 1,2,3-Thiadiazole Derivatives, J. Org. Chem. 2016, 81, 3553–3559. 39. P.-S. Wei, M.-X., Wang, D.-C. Xu and J.-W. Xie*, Synthesis of 2,3-Dihydrothieno(2,3‑b)quinolines and Thieno(2,3‑b)-quinolines via an Unexpected Domino Aza-MBH/Alkylation/Aldol Reaction, J. Org. Chem. 2016, 81(3), 1216–1222. 2015年 38. X.-Y. Zhang, L.-L. Hu, Z. Shen, Z.-Z. Chen, Z.-G. Xu, S.-Q. Li, J.-W. Xie* and H.-L. Cui*, Copper-Catalyzed Synthesis of Furo[3,2-c]coumarin And Dihydrofuro[3,2-c]coumarin Through Propargylation/Alkyne Oxacyclization/Isomerization Cascade Under Microwave Irradiation, Synlett., 2015, 2821-2825. 37. J.-S. Wu*, X. Zhang, Y.-L. Zhang and J.-W. Xie*, Synthesis and antifungal activities of novel polyheterocyclic spirooxindole derivatives, Org. Biomol. Chem., 2015, 13, 4967-4975. 36. W. Chen, R.-Z. Zhang, X.-Y. Lu, and J.-W. Xie, Asymmetric Synthesis of Highly Functionalized Cyclohexa-1,3-dienes via Organocatalyzed One-Pot Three-Component Domino Reaction of Malononitrile with α,β-Unsaturated Imines, J. Brazil. Chem. Soc., 2015, 26, 405-410. 35. X.-M. Zeng, C.-Y. Meng, J.-X. Bao, D.-C. Xu, J.-W. Xie* and W.-D. Zhu, Enantioselective Construction of Polyfunctionalized Spiroannulated Dihydrothiophenes via a Formal Thio [3 + 2] Cyclization, J. Org. Chem. 2015, 80, 11521-11528. 2014年 34. P. Sun, C.-Y. Meng, F. Zhou, X.-S. Li, J.-W. Xie,* Organocatalytic Asymmetric One-Pot Sequential Reaction: Synthesis of Highly Substituted Spirocyclohexanepyrazolones with Six Contiguous Stereogenic Carbons, Tetrahedron, 2014, 70, 9330-9336. 33. J.-J. Liang, J.-Y. Pan, D.-C. Xu, J.-W. Xie,* Construction of Polyheterocyclic Spirotetrahydrothiophene Derivatives via Sulfa-Michael/aldol Cascade Reaction, Tetrahedron Lett. 2014, 55, 6335–6338. 32. Z.-K. Fu, J.-Y. Pan, D.-C. Xu, J.-W. Xie,* Organocatalytic Domino Michael/Cyclization Reaction: Efficient Synthesis of Multi-functionalized Tetracyclic Spirooxindoles with Multiple Stereocenters, RSC Advances, 2014, 4, 51548 – 51557. 31. R.-Z. Zhang, C.-Y. Meng, J.-W. Xie,* M.-L. Xu and W.-D. Zhu, Base-Catalyzed Domino Michael-Alkylation-Rearrangement: A New Synthetic Route to Functionalized 2,3-Dihydrofurans, Eur. J. Org. Chem., 2014, 3104-3107. 30. J.-W. Xie*, M.-L. Xu, R.-Z. Zhang, J.-Y. Pan and W.-D. Zhu*, Organocatalytic Domino Reaction of Electron-Deficient 2,4-Dienes with 2-Halo-1,3-Dicarbonyl Compounds: A Highly Regio- and Stereoselective Approach to Functionalized Five-Membered Carbocycles, Adv. Synth. Catal., 2014, 356, 395-400. 2013年 29. Z.-W. Guo, X. Huang, J.-M. Mao, W.-D. Zhu and J.-W. Xie*, Diastereoselective synthesis of polysubstituted ∆1-pyrroline derivatives from in situ generated nitrile ylides, RSC Advances, 2013, 3, 25103-25109. 28. T. Shi, Z. Guo, H. Yu, J.-W. Xie*, Y. Zhong, W. Zhu*, Atom-Economic Synthesis of Optically Active Warfarin Anticoagulant over a Chiral MOF Organocatalyst, Adv. Synth. Catal., 2013, 355, 2538-2543. 27. X. Huang, Y.-R. Zhang, X.-S. Li, D.-C. Xu, J.-W. Xie*, Construction of Functionalized Spiro 1,4-Benzoxazine Oxindole Derivatives via Domino Mannich-Alkylation of α-Halocarbonyl Compounds with Imines, Tetrahedron Lett. 2013, 54, 5857-5860. 26. J.-Y. Pan, X.-S. Li, D.-C. Xu and J.-W. Xie*, Synthesis of Chiral 1,2-Dihydronaphtho[2,1-b] furans by Organocatalytic Domino Reactions Catalyzed with Multiple Catalysis, Aust. J. Chem. 2013, 66(11), 1415-1421. 25. Y.-R. Zhang, X. Huang, D.-C. Xu and J.-W. Xie*, Facile Domino Access to Unexpected Alkyl 3-Substituted-2-hydroxy-3,4-dihydro-2H- 1,4-benzoxazine-2-carboxylates, Aust. J. Chem. 2013, 66, 959–962. 2012年 24. H. Yu, J.-W. Xie*, Y. Zhong, F. Zhang, W. Zhu*, Catalysis Communications, 2012, 29, 101-104. 23. Z.-W. Guo, X.-S. Li, W.-D. Zhu, J.-W. Xie,* Eur. J. Org. Chem., 2012, 6924–6932. 22. Z.-W. Guo, J.-W. Xie,* C. Chen, and W. Zhu,* Org. Biomol. Chem. 2012, 10 (42), 8471 - 8477. 21. Y.-R. Zhang, F. Luo,* X.-J. Huang, J.-W. Xie,* Chem. Lett., 2012, 41, 777-779. 20. R. Z. Zhang, D. C. Xu, J. W. Xie*, Chin. J. Chem., 2012, 30, 1690-1694. 19. Y.-R. Zhang, J.-W. Xie*, X.-J. Huang, W.-D. Zhu*, Org. Biomol. Chem. 2012, 10, 6554-6561. 18. T. Wang, X.-C. Hu, X.-J. Huang, X.-Sheng Li, J.-Wu Xie*, J. Brazil. Chem. Soc., 2012, 23, 1119-1123. 17. W. Dong, D. Xu, J. Xie, Chin. J. Chem., 2012, 30, 1771-1774. 16. W.-K. Dong, X. Huang, D.-C. Xu*, X.-S. Li and J.-W. Xie*, J. Brazil. Chem. Soc., 2012, 23, 280-284. 15. P. Li, B.-T. Teng, F.-G. Jin, X.-S. Li, W.-D. Zhu, J.-W. Xie*, Org. Biomol. Chem., 2012, 10, 244-247. 2011年 14. Q.-B. Li, F.-T., Zhou, Z.-G. Liu, X.-F. Li, W.-D. Zhu, J.-W. Xie*, J. Org. Chem. 2011, 76, 7222-7228. 13. L.-P. Fan, W.-J Yang, D.-C. Xu, X.-S. Li, J.-W. Xie*, Synth. Comm., 2011, 41, 3376–3384.) 12. J.-W. Xie*, P. Li, T. Wang, F.-T. Zhou, Tetrahedron Lett. 2011, 52, 2379-2382. 2010年 11. L.-P Fan, P. Li, X.-S. Li, D.-C. Xu, M.-M. Ge, W.-D. Zhu, J.-W. Xie*, J. Org. Chem. 2010, 75, 8716-8719. 10. X. Huang, Y.-H. Wen, F.-T. Zhou, C. Chen, D.-C. Xu, J.-W. Xie*, Tetrahedron Lett. 2010, 51, 6637-6640. 9. P. Li, L.-L. Luo, X.-S. Li, J.-W. Xie*, Tetrahedron, 2010, 66, 7590-7594. 8. X. Huang, P. Li, X.-S. Li, D.-C. Xu, J.-W. Xie*, Org. Biomol. Chem., 2010, 8, 4527 - 4529. 7. J.-W. Xie*, L.-P. Fan, H. Su, X.-S. Li, D.-C. Xu, Org. Biomol. Chem., 2010, 8, 2117-2122. 2009年 6. J.-W. Xie*, X. Huang, L.-P. Fan, D.-C. Xu, X.-S. Li, H. Su, Y.-H. Wen, Adv. Synth. Catal., 2009, 351, 3077-3082. 5. J.-W. Xie*, Z. Wang , W.-J. Yang , L.-C. Kong , D.-C. Xu, Org. Biomol. Chem., 2009, 7, 4352 – 4354. 2006-2008年 4. J.-W. Xie, K. Yoshida, K. Takasu, and Y. Takemoto, Tetrahedron Lett. 2008, 49, 6910-6913. 3. J.-W. Xie, L. Yue, W. Chen, W. Du, J. Zhu, J.-G. Deng*, and Y.-C. Chen*, Org. Lett., 2007, 9, 413-415. 2. J.-W. Xie, W. Chen, R. Li, M. Zeng, W. Du, L. Yue, Y.-C. Chen*, Y. Wu, J. Zhu, and J.-G. Deng*, Angew. Chem. Int. Ed, 2007, 46, 389-392; Angew. Chem. 2007, 119, 393-396. ISSN: 1433-7851 1. J.-W. Xie, L. Yue, D. Xue, X.-L.Ma, Y.-C. Chen*, Y. Wu, J. Zhu, and J.-G. Deng*, Chem. Commun., 2006, 1563-1565.
四、授权发明专利: 15. 3,4-二氢-1H-螺[萘-2,1'-噻吩并色烯]衍生物及其合成方法和应用,谢建武,王经,授权日期:2021.2.19,专利号:201811072155.0(申请日2018.9.14) 14. 一种具有抗菌活性的4H-1,3-苯并噻嗪衍生物及其合成方法和应用,谢建武,董建连,卫培顺,专利号:2017101649037,授权日期:20201106(申请日:20170320) 13. 一种具有抗菌活性的2-芳基苯并吡喃并二氢噻吩衍生物及其合成方法和应用,谢建武,余李思晗,专利号:201810081917.7,授权日期:2019.10.25(申请日20180129) 12. 具有抗菌活性的3-溴代-3-硝基-2-芳基喹啉并硫吡喃衍生物及其合成方法和应用,谢建武,高志坚,专利号:201710875665.0,授权日期:2019.03.19(申请日:2017.9.25) 11. 一种具有抗菌活性的喹啉并硫吡喃衍生物及其合成方法和应用,谢建武,唐婷,王梦雪,专利号:ZL201710164995.9,授权日期:2018.8.7(申请日:20170320) 10. 一种具有抗菌活性的螺靛红硫脲衍生物及其合成方法和应用,谢建武,孙奇超,朱英超,专利号:ZL201611236774.X,授权日期:2018.8.7(申请日20161228) 9. 一种具有抗菌活性的双螺靛红呋喃衍生物及其合成方法和应用,谢建武,专利号ZL 201610967743.5,20161105(申请日20161101)授权日期:2018.7.3 8. 一种具有抗菌活性的手性螺1,2,3-噻二唑衍生物及其合成方法和应用,谢建武,曾雪梅等,专利号:ZL201610228834.7,授权日期:2018.06.29。(申请日20160413) 7. 一种具有抗菌活性的苯并吡喃并四氢噻吩衍生物及其合成方法和应用,谢建武,丁晨浩等,专利号:2016103340324,授权日期:2018.03.09。(申请日20160518) 6. 噻吩[2,3-b]喹啉衍生物及其合成方法和应用,谢建武,李丹妮,卫培顺,专利号:2015109989682,授权日期:2017.12.08。(申请日:20151225) 5. 1H-呋喃并[2,3-c]吡唑衍生物及其合成方法及应用, 谢建武;苏盛楠,专利号:201510242475.6,授权日期:2017.05.03(申请日:2015.5.12) 4. 手性的1,4-二氢吡喃(2,3-c)吡唑衍生物及其合成方法和应用,谢建武、孙平,专利号:ZL 201410115142.2,授权时间:2016.08.17,转让办理中。(申请日:2014.3.25) 3. 4,5-二羟基-3-H-螺[呋喃-2,3’-吲哚]-2’-酮衍生物及其合成方法和应用,谢建武、张雪,专利号:ZL201410026948.4,2016.01.06 2. 一种螺[萘满酮-四氢噻吩]衍生物的合成及抗菌活性研究,谢建武、潘金芸,专利号:ZL 201410173109.5,2015.12.02 1. 3-羟基-2,3-二氢苯并呋喃衍生物及其合成方法和应用,谢建武,专利号:ZL201110160447.1,2014.06.18 |